TY - JOUR AU - Junaid, Muhammad AU - Yan , Jianhua AU - Qi, Zhongquan AU - Haroon, Muhammad PY - 2022/09/23 Y2 - 2024/03/28 TI - Synthesis, characterization and antibacterial activity of ethylene di-amine and 2-hydroxybenzadehyde Schiff base and its metal complexes JF - Journal of Chemistry and Environment JA - JCE VL - 1 IS - 01 SE - Article DO - 10.56946/jce.v1i01.34 UR - https://www.jspae.com/index.php/jce/article/view/34 SP - 5-16 AB - <p>A number of modern techniques have been developed for the synthesis of Schiff bases. We reported the synthesis of ethylene di-amine and 2-hydroxybenzadehyde Schiff base (SB) via the condensation method. To remove phenolic hydrogen to form Schiff base it was reacted with sodium hydroxide and then treated with M(II) chloride (M=Fe, Cu, Zn, Ni and Sn) to fabricate their respective metal complexes<strong>. </strong>The synthesis of SB metal complexes and detailed functional group characterization were validated via Fourier transform infrared (FT-IR) spectroscopy. In the final SB, FT-IR results revealed a vibrational peak at 1614 cm<sup>-1</sup>, which was credited to the –C=N part. The absence of a vibration band for –OH vibration on 1613 cm<sup>-1</sup> and the presence of a novel band in the 659 to 586 cm<sup>-1</sup> range were due to the metal-oxygen bond, confirming the synthesis of metal complexes. The Schiff base showed high antibacterial activity against <em>E. coli, Pseudomonas aeruginosa, Salmonella typhi, S.aureus </em>and <em>Bacillus </em>whereas <em>Streptococcus</em> was found resistant. Cu, Fe and Sn coordination improved Schiff base activity while Ni coordination did not affect the activity. Similarly, Fe and Sn complex had no effect on <em>E. coli</em>. In comparison with standard Ciprofloxacin, the activities of respective metal complexes were low.</p> ER -